Description

(S)-n-[4-(4-Acetamido-4-Phenyl-1-Piperidyl)-2-(3,4-Dichlorophenyl)Butyl ]-n-Methylbenzamide--Fumaric Acid (1:1) is a high-purity, non-racemic pharmaceutical intermediate and active ingredient. This compound matters for its role as a key chiral building block in the synthesis of advanced therapeutic agents, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D laboratories and manufacturers developing novel central nervous system (CNS) and receptor-targeted drugs.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the multi-step synthesis of proprietary drug candidates.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of new chemical entities (NCEs), particularly for neurological targets.
• Pharmacological Research: Serves as a reference standard and tool compound for in-vitro and in-vivo studies of receptor binding and activity.
• Process Chemistry & Scale-Up: Supports route scouting, optimization, and cGMP manufacturing for clinical trial material.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry and synthetic methodology projects.

Basic Information

Product Name	(S)-n-[4-(4-Acetamido-4-Phenyl-1-Piperidyl)-2-(3,4-Dichlorophenyl)Butyl ]-n-Methylbenzamide--Fumaric Acid (1:1)
CAS No.	176381-97-8
Molecular Formula	C31H33Cl2N3O2 • C4H4O4
Molecular Weight	Contact for details
Synonyms	(S)-N-[4-(4-Acetamido-4-phenylpiperidin-1-yl)-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide fumarate (1:1); (S)-N-[4-[4-(Acetylamino)-4-phenyl-1-piperidinyl]-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide (2E)-2-butenedioate (1:1); L-771,688 fumarate; L771688 fumarate; (S)-L-771,688 fumarate; Benzamide, N-[4-[4-(acetylamino)-4-phenyl-1-piperidinyl]-2-(3,4-dichlorophenyl)butyl]-N-methyl-, (2E)-2-butenedioate (1:1), (S)-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data to support your development and regulatory needs. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are available upon request. Specifications are aligned with ICH guidelines for impurities and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and handling properties. Long-term storage under inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.