Description

Boc-Dl-Ala-Nh-Nbu CAS NO 176249-81-3 is a protected amino acid derivative, specifically an N-Boc-protected alanine hydrazide, serving as a crucial building block in advanced organic synthesis. Its primary value lies in providing a reactive hydrazide handle for the controlled formation of heterocycles and peptide mimetics, while the Boc group offers orthogonal protection for selective deprotection strategies. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in developing novel active ingredients and complex molecular architectures.

Application

• Peptidomimetic Synthesis: A key intermediate for constructing peptide backbone modifications and non-natural amino acid analogs.
• Heterocyclic Chemistry: Utilized as a precursor in the synthesis of pyrazoles, triazoles, and other nitrogen-containing heterocycles via cyclization reactions.
• Pharmaceutical Intermediate: Serves as a building block in the research and development of new drug candidates, particularly protease inhibitors and receptor ligands.
• Bioconjugation: The reactive hydrazide group enables site-specific conjugation to aldehydes and ketones, useful in labeling and linker chemistry.
• Agrochemical Research: Employed in the synthesis of novel active ingredients with potential herbicidal or insecticidal properties.
• Material Science: Used in the development of specialty polymers and dendrimers with tailored functional groups.

Basic Information

Product Name	Boc-Dl-Ala-Nh-Nbu
CAS No.	176249-81-3
Molecular Formula	C₁₂H₂₅N₃O₃
Molecular Weight	259.35 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-DL-alanine hydrazide; tert-Butyl (1-hydrazinyl-1-oxopropan-2-yl)carbamate; Boc-DL-alanine hydrazide; DL-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide; Boc-Ala-NHNH₂; (RS)-2-[(tert-Butoxycarbonyl)amino]propanehydrazide; N-Boc-DL-alanine hydrazide; 2-[(tert-Butoxycarbonyl)amino]propanoic acid hydrazide
EINECS	Contact for details

Quality Control

Our Boc-Dl-Ala-Nh-Nbu is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and loss on drying for moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.