Description

4-Pentenenitrile, 2-Acetyl-2-Methyl-, (R)- (9Ci) is a chiral, high-purity nitrile compound with a defined stereochemistry, serving as a critical chiral building block in advanced organic synthesis. Its value lies in enabling the stereoselective construction of complex molecules, which is essential for developing pharmaceuticals and fine chemicals with high biological specificity. This product is primarily needed by research and development chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value intermediates.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key precursor for the stereoselective synthesis of active pharmaceutical ingredients (APIs), particularly in routes requiring the (R)-configured stereocenter.
• Agrochemical Research & Development: Used in the development of novel, enantiomerically pure pesticides and herbicides where specific chirality impacts biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing chiral ligands and organocatalysts used in asymmetric catalysis.
• Fine Chemical and Flavor/Fragrance Synthesis: Employed in the production of enantiomerically enriched fine chemicals and aroma compounds.
• Academic and Industrial R&D: A valuable reagent for methodological development in organic chemistry and for exploring new synthetic pathways.

Basic Information

Product Name	4-Pentenenitrile, 2-Acetyl-2-Methyl-, (R)- (9Ci)
CAS No.	176212-05-8
Molecular Formula	C8H11NO
Molecular Weight	137.18 g/mol
Synonyms	(R)-2-Acetyl-2-methyl-4-pentenenitrile; (R)-3-Methyl-4-pentenenitrile-2-one; 2-Acetyl-2-methyl-4-pentenenitrile, (R)-; (R)-2-Methyl-2-acetyl-4-pentenenitrile; 4-Pentenenitrile, 2-acetyl-2-methyl-, (R)-; (R)-enantiomer of 2-Acetyl-2-methyl-4-pentenenitrile
EINECS	Contact for details

Quality Control

Every batch of (R)-2-Acetyl-2-methyl-4-pentenenitrile is produced and tested under a strict quality management system to ensure high chemical and chiral purity. Our standard quality commitment includes comprehensive analysis by HPLC, GC, and chiral methods to verify identity, purity, and enantiomeric excess (e.e.). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider maintaining the material under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.