Description

Boc-D-4-Iodophenylalanine CAS NO 176199-35-2 is a protected, non-natural amino acid derivative featuring an iodine substituent on the aromatic ring, which serves as a versatile handle for further chemical modification. This chiral building block is essential for the synthesis of complex peptides and peptidomimetics with enhanced stability and targeted bioactivity. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers in the development of novel therapeutic agents, diagnostic probes, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate iodinated phenylalanine residues, enabling downstream radioiodination or cross-coupling reactions.
• Chemical Biology Probes: Serves as a precursor for creating labeled peptides used in imaging studies, target identification, and mechanism-of-action research.
• Material Science: Employed in the synthesis of functionalized polymers and advanced organic materials where the iodine atom facilitates further derivatization.
• Agrochemical Research: Used as a building block in the design of novel bioactive compounds with potential pesticidal or herbicidal activity.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting studies in asymmetric synthesis, medicinal chemistry, and organocatalysis.

Basic Information

Product Name	Boc-D-4-Iodophenylalanine
CAS No.	176199-35-2
Molecular Formula	C₁₄H₁₈INO₄
Molecular Weight	391.20 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-4-iodophenylalanine; Boc-D-Phe(4-I)-OH; (2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(4-iodophenyl)propanoic acid; tert-Butyloxycarbonyl-D-4-iodophenylalanine; Boc-D-4-Iodo-Phe-OH; D-4-Iodophenylalanine, N-BOC-protected; N-Boc-4-iodo-D-phenylalanine
EINECS	Contact for details

Quality Control

Our Boc-D-4-Iodophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%
Solubility	Soluble in DMF, DMSO; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.