Description

Fmoc-Dl-1-Naphthylalanine is a protected, non-natural amino acid derivative used in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the bulky, hydrophobic 1-naphthylalanine side chain into peptide sequences, which can be critical for modulating biological activity, stability, and binding affinity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected building block for the automated synthesis of custom peptides.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates to enhance lipophilicity, receptor binding, or metabolic stability.
• Structure-Activity Relationship (SAR) Studies: Used to explore the effect of aromatic, hydrophobic residues on peptide function and conformation.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescent or affinity-labeled peptide probes due to the naphthalene moiety's properties.
• Material Science: Potential use in the synthesis of peptide-based polymers or nanomaterials requiring specific aromatic interactions.

Basic Information

Product Name	Fmoc-Dl-1-Naphthylalanine
CAS No.	176036-48-9
Molecular Formula	C₂₈H₂₃NO₄
Molecular Weight	437.49 g/mol
Synonyms	Fmoc-1-Nal-OH; Fmoc-DL-1-Nal; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-naphthylalanine; Nα-Fmoc-1-naphthylalanine; Fmoc-Naphthylalanine; 1-Naphthylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(naphthalen-1-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-1-Naphthylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing purity, chiral composition, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Optical Purity (DL Ratio)	~50:50 (Racemic mixture)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.