Description

1,1'-[1,2-Phenylenebis-(Methylene)]-Bis-(1,4,7,10-Tetraazacyclododecane) Octahydrochloride is a high-purity, polyazamacrocycle-based chelating agent, specifically a functionalized cyclen derivative. This compound is critically important for advanced research and development in radiopharmaceuticals and diagnostic imaging, where it acts as a sophisticated bifunctional chelator for metal ions. It is primarily needed by pharmaceutical R&D teams, radiochemistry laboratories, and manufacturers of contrast agents for MRI and nuclear medicine applications.

Application

• Bifunctional Chelator for Radiopharmaceuticals: Serves as a key linker for attaching radioisotopes (e.g., 68Ga, 177Lu, 111In) to targeting biomolecules like peptides and antibodies for targeted radiotherapy and PET/SPECT imaging.
• MRI Contrast Agent Precursor: Used in the synthesis of novel gadolinium(III) or other lanthanide-based contrast agents for magnetic resonance imaging (MRI).
• Research Chemical in Coordination Chemistry: Employed in academic and industrial research to study complexation kinetics, stability constants, and the development of new metal-organic frameworks (MOFs) or catalysts.
• Diagnostic Kit Formulation: A critical component in the development of cold kits for the convenient, on-site preparation of radiopharmaceuticals.
• Theragnostic Agent Development: Central to creating theragnostic pairs, where a single chelator platform can be used with both diagnostic and therapeutic radioisotopes.

Basic Information

Item	Details
Product Name	1,1'-[1,2-Phenylenebis-(Methylene)]-Bis-(1,4,7,10-Tetraazacyclododecane) Octahydrochloride
CAS No.	175854-50-9
Molecular Formula	C30H68Cl8N12
Molecular Weight	822.58 g/mol
Synonyms	p-SCN-Bn-DOTAM; 2,2',2'',2'''-(1,2-Phenylenebis(methylene))bis(azanetriyl))tetraacetic acid octahydrochloride; DOTAM-Benzyl-p-SCN; p-SCN-Bn-DOTAM·8HCl; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 2,2',2'',2'''-(1,2-phenylenebis(methylene))bis(azanetriyl))tetra-, octahydrochloride; Bifunctional DOTAM chelator; SCN-Bn-DOTAM; Thiocyanatobenzyl-DOTAM octahydrochloride
EINECS	Contact for details

Quality Control

Our 1,1'-[1,2-Phenylenebis-(Methylene)]-Bis-(1,4,7,10-Tetraazacyclododecane) Octahydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical research and development. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.