Description

4-Difluoromethoxy-Biphenyl is a high-purity, fluorinated biphenyl derivative with the CAS number 175838-98-9. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block in organic synthesis. It is primarily required by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the stability imparted by the difluoromethoxy group.
• Liquid Crystal Materials: Serves as a core component or precursor in the manufacture of fluorinated liquid crystals for advanced display technologies.
• Organic Light-Emitting Diodes (OLEDs): Acts as a precursor for electron-transport materials or host materials in OLED device fabrication.
• Polymer Chemistry: Utilized as a monomer or modifier to introduce fluorinated aromatic units into high-performance polymers, enhancing their thermal and chemical resistance.
• Chemical Research: Employed in academic and industrial laboratories for method development and as a standard in fluorinated compound studies.

Basic Information

Product Name	4-Difluoromethoxy-Biphenyl
CAS No.	175838-98-9
Molecular Formula	C13H10F2O
Molecular Weight	220.22 g/mol
Synonyms	1,1'-Biphenyl, 4-(difluoromethoxy)-; 4-(Difluoromethoxy)-1,1'-biphenyl; p-(Difluoromethoxy)biphenyl; [1,1'-Biphenyl]-4-yl difluoromethyl ether; 4-Biphenylyl difluoromethyl ether; DFMB; Difluoromethoxy biphenyl
EINECS	Contact for details

Quality Control

Our 4-Difluoromethoxy-Biphenyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, impurity profiles, and physical characteristics.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.