Description

(R)-4-Chlorokynurenine is a high-purity, enantiomerically pure derivative of the endogenous amino acid kynurenine. This compound matters as a critical research-grade intermediate and reference standard in neuroscience and pharmaceutical development, specifically targeting the glycine site of the NMDA receptor. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and contract manufacturing organizations (CMOs) focused on developing novel neuroprotective agents, antidepressants, and treatments for neurological disorders.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of advanced NMDA receptor antagonists and other central nervous system (CNS) active compounds.
• Biochemical Research: Used as a potent and selective tool compound to study the glycine co-agonist site of the NMDA receptor complex in neurological disease models.
• Reference Standard: Serves as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Preclinical Development: Employed in in vitro and in vivo studies to investigate neuroprotection, mechanisms of excitotoxicity, and potential therapeutic pathways for stroke, depression, and chronic pain.
• Metabolite Studies: Used in research related to the kynurenine pathway, a critical metabolic route implicated in immune regulation and neurological function.

Basic Information

Product Name	(R)-4-Chlorokynurenine
CAS No.	175777-22-7
Molecular Formula	C10H11ClN2O3
Molecular Weight	242.66 g/mol
Synonyms	(R)-2-Amino-4-(2-chlorophenyl)-4-oxobutanoic Acid; (R)-4-Chloro-DL-kynurenine; (R)-4-Cl-KYN; (2R)-2-Amino-4-(2-chlorobenzoyl)butanoic Acid; (R)-4-Chlorokynurenine; AV-101 (Enantiomer); L-4-Chlorokynurenine (Enantiomer); (R)-4-Chloro-kynurenine
EINECS	Contact for details

Quality Control

Our (R)-4-Chlorokynurenine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, NMR and IR for structural confirmation, and stringent control of related substances and residual solvents. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.