Description

1-(4-Amino-2-Fluoro-5-Methoxy-Phenyl)-Ethanone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors, where its unique fluorine and amino substituents enable precise modulation of biological activity and physicochemical properties. It is primarily needed by research chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in kinase inhibitors, anti-cancer agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic core and reactive sites.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the design of molecular probes, affinity tags, and photoaffinity labeling reagents.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and development-scale batches.

Basic Information

Product Name	1-(4-Amino-2-Fluoro-5-Methoxy-Phenyl)-Ethanone
CAS No.	175711-82-7
Molecular Formula	C9H10FNO2
Molecular Weight	183.18 g/mol
Synonyms	2'-Fluoro-4'-amino-5'-methoxyacetophenone; 4'-Amino-2'-fluoro-5'-methoxyacetophenone; 1-(4-Amino-2-fluoro-5-methoxyphenyl)ethanone; 4-Acetylamino-2-fluoroanisole (related); Ethanone, 1-(4-amino-2-fluoro-5-methoxyphenyl)-; 2-Fluoro-4-amino-5-methoxyacetophenone; 5-Methoxy-2-fluoro-4-aminoacetophenone
EINECS	Contact for details

Quality Control

Our 1-(4-Amino-2-Fluoro-5-Methoxy-Phenyl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.