Description

Ethyl 2,2-Difluoro-2-(3-(Trifluoromethyl)Phenyl)Acetate is a high-value fluorinated organic building block characterized by its unique phenylacetate structure with multiple fluorine substitutions. This compound is critical for introducing lipophilicity and metabolic stability into target molecules, making it a sought-after intermediate in advanced synthesis. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, where the difluoromethyl and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a fluorinated building block for electronic chemicals used in display technologies, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to incorporate fluorine into polymer side chains, enhancing material properties such as chemical resistance, weatherability, and surface energy.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the 2-(3-(Trifluoromethyl)phenyl)-2,2-difluoroacetyl moiety into complex molecules via esterification or transesterification reactions.
• Fluorine-19 NMR Spectroscopy: Can be used as a reference standard or probe molecule in analytical chemistry due to its distinct 19F NMR signature.

Basic Information

Item	Details
Product Name	Ethyl 2,2-Difluoro-2-(3-(Trifluoromethyl)Phenyl)Acetate
CAS No.	175543-24-5
Molecular Formula	C11H9F5O2
Molecular Weight	268.18 g/mol
Synonyms	Ethyl α,α-Difluoro-3-(trifluoromethyl)phenylacetate; 2,2-Difluoro-2-(3-(trifluoromethyl)phenyl)acetic acid ethyl ester; Ethyl 2,2-Difluoro-2-(m-(trifluoromethyl)phenyl)acetate; Ethyl [3-(Trifluoromethyl)phenyl]difluoroacetate; α,α-Difluoro-α-(3-trifluoromethylphenyl)acetic Acid Ethyl Ester; 3-(Trifluoromethyl)benzeneacetic acid, 2,2-difluoro-, ethyl ester; Ethyl (3-Trifluoromethylphenyl)difluoroacetate
EINECS	Contact for details

Quality Control

Our production of Ethyl 2,2-Difluoro-2-(3-(Trifluoromethyl)Phenyl)Acetate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is manufactured and tested in facilities operating under cGMP (current Good Manufacturing Practice) guidelines where applicable. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request. We ensure compliance with relevant global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.