Description

2-(Difluoromethoxy)Bromobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique difluoromethoxy and bromo substituents, which enable precise structural modifications in complex molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the difluoromethoxy pharmacophore for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or precursor in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form biaryl structures.
• Fluorine Chemistry Research: An essential reagent in academic and industrial laboratories focused on exploring new methodologies in organofluorine chemistry.
• Ligand and Catalyst Development: Utilized for constructing sophisticated ligand frameworks for catalysis and molecular recognition applications.

Basic Information

Product Name	2-(Difluoromethoxy)Bromobenzene
CAS No.	175278-33-8
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-2-(difluoromethoxy)benzene; o-(Difluoromethoxy)bromobenzene; 2-Bromophenyl difluoromethyl ether; Benzene, 1-bromo-2-(difluoromethoxy)-; Bromobenzene, 2-(difluoromethoxy)-; (2-Bromophenoxy)difluoromethane
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethoxy)Bromobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures material consistency and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider maintaining under an inert atmosphere to preserve optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.