Description

2-Bromo-4,6-Difluoroiodobenzene is a high-purity, multi-halogenated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique reactivity profile, enabling precise structural modifications in complex molecule construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing halogenated aryl groups via cross-coupling reactions like Suzuki or Negishi.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the difluoro and bromo/iodo substituents confer specific biological activity and stability.
• Material Science Research: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions, where the iodine and bromine atoms offer orthogonal reactivity for sequential functionalization.
• Ligand and Catalyst Development: Employed in the preparation of complex ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Used to synthesize tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	2-Bromo-4,6-Difluoroiodobenzene
CAS No.	175278-11-2
Molecular Formula	C6H2BrF2I
Molecular Weight	318.89 g/mol
Synonyms	1-Bromo-3,5-difluoro-2-iodobenzene; 2-Iodo-1,3-difluoro-5-bromobenzene; Benzene, 2-bromo-1,3-difluoro-4-iodo-; 2-Bromo-1,3-difluoro-4-iodobenzene; 4-Iodo-2,6-difluorobromobenzene
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-4,6-Difluoroiodobenzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency, which is critical for reproducible research and process scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by techniques such as HPLC, GC, and NMR is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials and strong oxidizing agents. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.