Description

(2,4-Difluorophenylthio)Acetonitrile is a versatile sulfur-containing nitrile building block, valued for its role as a key synthetic intermediate in advanced organic synthesis. Its molecular structure, featuring both a thioether linkage and a reactive nitrile group, makes it a critical precursor for constructing complex heterocyclic and pharmaceutical scaffolds. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing benzothiophene or related heterocyclic cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require difluorophenyl motifs for enhanced bioactivity and stability.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic electronic materials and polymers where the incorporation of sulfur and fluorine atoms can modify electronic properties.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	(2,4-Difluorophenylthio)Acetonitrile
CAS No.	175277-63-1
Molecular Formula	C8H5F2NS
Molecular Weight	185.19 g/mol
Synonyms	2-[(2,4-Difluorophenyl)thio]acetonitrile; Acetonitrile, (2,4-difluorophenylthio)-; 2,4-Difluorophenylthiocyanatomethane; (2,4-DFPT)Acetonitrile; 2-(2,4-Difluorophenylsulfanyl)acetonitrile; 2,4-Difluorothiophenoxyacetonitrile; α-[(2,4-Difluorophenyl)thio]acetonitrile
EINECS	Contact for details

Quality Control

Our (2,4-Difluorophenylthio)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, purity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.