Description

Tris[3,5-Bis(Trifluoromethyl)Phenyl]Phosphine is a highly specialized organophosphorus ligand characterized by its electron-deficient, sterically demanding triarylphosphine structure. This compound matters for its exceptional ability to stabilize electron-rich metal centers and modulate catalytic activity in demanding cross-coupling and other transition metal-catalyzed reactions. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel synthetic pathways and optimizing high-value chemical production.

Application

• As a ligand in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Buchwald-Hartwig amination, and Negishi couplings, particularly for challenging substrates.
• Catalyst component for hydrofunctionalization reactions including hydroamination and hydrophosphination.
• Precursor for the synthesis of specialized ionic liquids and phosphonium salts with unique solubility properties.
• Key reagent in the research and development of novel organometallic complexes for asymmetric catalysis.
• Used in the synthesis of electronic materials and OLED intermediates where precise control over molecular architecture is critical.
• Facilitates C-H activation and C-F bond formation processes in medicinal chemistry for drug discovery.

Basic Information

Product Name	Tris[3,5-Bis(Trifluoromethyl)Phenyl]Phosphine
CAS No.	175136-62-6
Molecular Formula	C24H9F18P
Molecular Weight	688.28 g/mol
Synonyms	Tris[3,5-bis(trifluoromethyl)phenyl]phosphine; Tris(3,5-bis(trifluoromethyl)phenyl)phosphane; Phosphorous tris[3,5-bis(trifluoromethyl)phenyl] ester; P(3,5-(CF3)2C6H3)3; Tris(3,5-di(trifluoromethyl)phenyl)phosphine; (3,5-Bis(trifluoromethyl)phenyl)phosphine, tris-; Tris(alpha,α-bis(trifluoromethyl)-m-tolyl)phosphine
EINECS	Contact for details

Quality Control

Our Tris[3,5-Bis(Trifluoromethyl)Phenyl]Phosphine undergoes rigorous quality testing to ensure batch-to-batch consistency and compliance with high-purity reagent standards. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to strict in-process controls and utilize advanced analytical techniques, including NMR and HPLC, to guarantee the product meets the exacting requirements of catalytic and synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at room temperature (15-25°C). Due to its sensitivity to oxidation, the container should only be opened in a controlled, oxygen-free environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR	Conforms
Melting Point	Contact for details
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.