Description

4-(2-Bromoethyl)-1,2-Difluorobenzene is a versatile fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a reactive bromoethyl side chain and difluorobenzene core, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries, where it serves as a key precursor for active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atoms to enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, where the difluorobenzene unit contributes to desired electronic and morphological properties.
• Cross-Coupling Reactions: The bromoethyl moiety acts as an effective handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create extended aromatic systems.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers, including polyarylates and polyimides, for high-performance coatings and engineering plastics.
• Chemical Biology Probe Development: Utilized in the synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	4-(2-Bromoethyl)-1,2-Difluorobenzene
CAS No.	175018-77-6
Molecular Formula	C8H7BrF2
Molecular Weight	221.04 g/mol
Synonyms	1-(2-Bromoethyl)-2,3-Difluorobenzene; 2,3-Difluoro-β-bromoethylbenzene; 2-(2,3-Difluorophenyl)ethyl Bromide; (2-Bromoethyl)-2,3-difluorobenzene; 4-Bromoethyl-1,2-difluorobenzene; 2,3-Difluoro-1-bromoethylbenzene; 175018-77-6; 4-(2-Bromoethyl)-o-difluorobenzene
EINECS	Contact for details

Quality Control

Our production of 4-(2-Bromoethyl)-1,2-Difluorobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthesis workflows. Each lot is characterized using advanced analytical techniques including GC, HPLC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support custom purity requirements for specific applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.