Description

(1R,2R)-(+)-1,2-Diaminocyclohexane-N,N'-Bis(2-Diphenylphosphino-1-Naphthoyl) is a highly specialized, chiral bisphosphine ligand crucial for enabling asymmetric catalysis in advanced organic synthesis. Its value lies in its ability to impart exceptional enantioselectivity and high catalytic activity in transition metal-catalyzed reactions, directly impacting the efficiency and purity of final products. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who are developing novel chiral molecules, including active pharmaceutical ingredients (APIs) and high-value intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, a key step in producing single-enantiomer pharmaceuticals.
• Pharmaceutical Intermediate Synthesis: Critical for constructing complex, chiral scaffolds found in a wide range of therapeutic agents, including cardiovascular, antiviral, and anticancer drugs.
• Agrochemical Development: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators to enhance efficacy and reduce environmental impact.
• Fine Chemical and Fragrance Manufacturing: Enables the production of high-purity chiral flavors, fragrances, and specialty materials where optical purity is paramount.
• Academic and Industrial R&D: A valuable tool for methodology development in asymmetric synthesis and catalysis research within university and corporate laboratories.
• Catalyst Screening Libraries: Serves as a key component in high-throughput screening for discovering new catalytic systems for challenging transformations.

Basic Information

Product Name	(1R,2R)-(+)-1,2-Diaminocyclohexane-N,N'-Bis(2-Diphenylphosphino-1-Naphthoyl)
CAS No.	174810-09-4
Molecular Formula	C58H48N2O2P2
Molecular Weight	891.0 g/mol
Synonyms	(1R,2R)-DACH-Naphthyl Trost Ligand; (R,R)-DACH-Naphthyl Trost Ligand; (1R,2R)-1,2-Diaminocyclohexane-N,N'-bis(2-(diphenylphosphino)-1-naphthamide); Trost Ligand Derivative; (R,R)-DACH-Naphthoyl Phosphine Ligand; (1R,2R)-DACH-N,N'-Bis(2-Diphenylphosphino-1-naphthoyl); Chiral DACH-Based Bisphosphine Ligand; (R,R)-1,2-Diaminocyclohexane N,N'-bis(2-diphenylphosphino-1-naphthoic acid amide)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with the high-purity standards required for sensitive catalytic applications. Every batch is characterized using advanced analytical techniques to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) are provided, detailing key parameters such as enantiomeric excess (ee) and assay by HPLC and NMR. We adhere to strict internal quality management protocols to ensure batch-to-batch consistency and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. Allow the container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystals
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.