Description

Fmoc-n-(tert-Butyloxycarbonylethyl)-Glycine is a specialized, protected amino acid derivative designed for advanced peptide synthesis. This compound matters because it provides orthogonal protection strategies, enabling the precise and sequential construction of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, and for use in solid-phase peptide synthesis (SPPS) platforms.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the automated, sequential assembly of peptides on resin.
• Pharmaceutical R&D: Synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Incorporation into non-natural peptide structures to enhance stability, bioavailability, or activity.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive molecules.
• Bioconjugation: Serves as a linker or modified amino acid in the synthesis of peptide-protein or peptide-small molecule conjugates.
• Academic Research: Fundamental studies in peptide chemistry, biochemistry, and molecular biology.

Basic Information

Product Name	Fmoc-n-(tert-Butyloxycarbonylethyl)-Glycine
CAS No.	174799-89-4
Molecular Formula	C₂₄H₂₇NO₆
Molecular Weight	425.47 g/mol
Synonyms	Fmoc-N-(Boc-aminoethyl)-Glycine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-[2-[(tert-butoxycarbonyl)amino]ethyl]glycine; Fmoc-N(Boc-Ae)-OH; Fmoc-N-(Boc-2-aminoethyl)glycine; N-{2-[(tert-Butoxycarbonyl)amino]ethyl}-N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycine; N-Fmoc-N'-(tert-butoxycarbonyl)-1,2-diaminoethane acetic acid; (2-{[(9H-Fluoren-9-ylmethoxy)carbonyl][(2-{[(tert-butoxycarbonyl)amino]ethyl})amino]acetic acid
EINECS	Contact for details

Quality Control

Our Fmoc-n-(tert-Butyloxycarbonylethyl)-Glycine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and solvent residues is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Keep the container tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.