Description

(1R,2R)-N,N′-Bis[2-(Diphenylphosphino)Benzyl]Cyclohexane-1,2-Diamine is a sophisticated chiral bisphosphine-diamine hybrid ligand, representing a pinnacle of design in asymmetric catalysis. Its core value lies in enabling highly enantioselective transformations, crucial for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control for manufacturing active ingredients and advanced materials.

Application

This advanced ligand is engineered for high-performance asymmetric catalysis. Key application areas include:

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, ketones, and imines, critical for producing chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Enables the production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Facilitates asymmetric C-C and C-X bond-forming reactions for creating complex fragrance, flavor, and electronic chemical intermediates.
• Academic & Industrial R&D: Serves as a key tool for developing new catalytic methodologies and exploring novel reaction pathways in process chemistry.
• Transition Metal Catalyst Preparation: Forms active complexes with Rh, Ru, and Ir for a wide range of enantioselective catalytic cycles.

Basic Information

Product Name	(1R,2R)-N,N′-Bis[2-(Diphenylphosphino)Benzyl]Cyclohexane-1,2-Diamine
CAS No.	174758-63-5
Molecular Formula	C46H46N2P2
Molecular Weight	688.82 g/mol
Synonyms	(1R,2R)-N,N'-Bis[2-(Diphenylphosphino)benzyl]-1,2-cyclohexanediamine; (1R,2R)-Cyclohexanediamine, N,N'-bis[2-(diphenylphosphino)benzyl]-; (R,R)-DACH-Phenyl Trost Ligand; (R,R)-Trost Ligand; (1R,2R)-1,2-Diaminocyclohexane Derivative; Chiral Diphosphine-Diamine Ligand; Trost-type Ligand; (R,R)-BDPP-DACH Hybrid Ligand
EINECS	Contact for details

Quality Control

Our production of (1R,2R)-N,N′-Bis[2-(Diphenylphosphino)Benzyl]Cyclohexane-1,2-Diamine adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot undergoes comprehensive analysis, including chiral purity verification by HPLC, elemental analysis, and spectroscopic identification (NMR, IR). Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP manufacturing standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. The compound is easily oxidized; therefore, handling and packaging should be performed in a controlled, oxygen-free environment. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H, ³¹P)
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.