Description

(S,S)-(-)-2,2'-Bis[(R)-(N,n-Dimethylamino)(Phenyl)Methyl]-1,1'-Bis(Diphenylphosphino)Ferrocene CAS NO 174467-31-3 is a highly specialized, chiral ferrocenyl diphosphine ligand, a cornerstone in asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and high catalytic activity in a range of transition metal-catalyzed reactions. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for synthesizing chiral intermediates and active ingredients.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing single-enantiomer pharmaceutical actives.
• Asymmetric C-C Bond Formation: Enables highly enantioselective cross-coupling, allylic substitution, and hydroformylation reactions for constructing complex chiral molecules.
• Pharmaceutical Intermediate Synthesis: Used in the development and commercial-scale production of chiral drugs, including β-blockers, antihypertensives, and antiviral agents.
• Agrochemical Synthesis: Facilitates the creation of enantiomerically pure herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Fine Chemical and Flavor/Fragrance Production: Applied in the synthesis of high-value chiral compounds for flavors, fragrances, and advanced materials.
• Academic and Industrial Catalyst Research: Serves as a benchmark ligand in methodology development and the discovery of new catalytic transformations.

Basic Information

Product Name	(S,S)-(-)-2,2'-Bis[(R)-(N,n-Dimethylamino)(Phenyl)Methyl]-1,1'-Bis(Diphenylphosphino)Ferrocene
CAS No.	174467-31-3
Molecular Formula	C58H56FeN2P2
Molecular Weight	883.85 g/mol
Synonyms	(S,S)-(-)-Bis[(R)-(N,N-Dimethylamino)(phenyl)methyl]-1,1'-bis(diphenylphosphino)ferrocene; (S,S)-(-)-2,2'-Bis[(R)-(N,N-Dimethylamino)(Phenyl)Methyl]-1,1'-Bis(Diphenylphosphino)Ferrocene; Josiphos SL-J009-1; (S,S)-Josiphos; (S,S)-(-)-1-[(R)-1-(Dimethylamino)ethyl]-2-(diphenylphosphino)ferrocene; (S,S)-(-)-[2-(Dimethylamino)ethyl]diphenylphosphinoferrocene; Chiral Ferrocenyl Diphosphine Ligand; SL-J009-1
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is synthesized and purified under stringent conditions to ensure exceptional enantiomeric purity and catalytic performance. Our products undergo rigorous quality testing, including chiral HPLC, NMR, and elemental analysis, to ensure compliance with the high standards required for asymmetric synthesis. Certificates of Analysis (COA) detailing purity, enantiomeric excess (ee), and full analytical data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.