Description

H-D-Asp(Obzl)-Obzl.Hcl is a protected aspartic acid derivative, specifically the hydrochloride salt of the dibenzyl ester of D-aspartic acid. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediates: Serves as a key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate D-aspartic acid residues with protected side chains.
• Biochemical Research: Employed in studies of enzyme-substrate interactions, receptor binding, and the structure-activity relationships (SAR) of peptides.
• Protease Inhibitor Development: Acts as a precursor in the creation of selective inhibitors for aspartic proteases.
• Conjugation Chemistry: The benzyl ester protecting groups allow for selective deprotection, enabling site-specific conjugation or further functionalization.
• Standards and References: Utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	H-D-Asp(Obzl)-Obzl.Hcl
CAS No.	174457-99-9
Molecular Formula	C19H21NO4 • HCl
Molecular Weight	363.83 g/mol (Free base: 327.38 g/mol)
Synonyms	H-D-Asp(OBzl)-OBzl hydrochloride; D-Aspartic acid dibenzyl ester hydrochloride; (R)-2-Amino-3-(benzyloxycarbonyl)propanoic acid benzyl ester hydrochloride; D-Asp(OBzl)2•HCl; Benzyl D-aspartate hydrochloride; D-Aspartic acid β-benzyl ester α-benzyl ester hydrochloride; Fmoc-D-Asp(OBzl)-OH precursor; D-Aspartic acid dibenzyl ester HCl salt
EINECS	Contact for details

Quality Control

Our H-D-Asp(Obzl)-Obzl.Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.