Description

Diethyl (4-Fluorobenzoyl)Malonate is a high-purity fluorinated malonate ester derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the strategic incorporation of the fluorine atom and the reactive malonate moiety, enabling precise molecular construction for complex target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated herbicides, fungicides, and plant growth regulators, where fluorine enhances bioavailability and stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic frameworks with tailored properties.
• Chemical Research & Development: A versatile reagent for constructing complex heterocycles and carbon-chain extensions via Claisen condensation and related reactions in medicinal chemistry programs.
• Fluorine Chemistry Studies: Employed as a model substrate to study the influence of fluorine substitution on reaction kinetics and molecular conformation in synthetic pathways.

Basic Information

Product Name	Diethyl (4-Fluorobenzoyl)Malonate
CAS No.	174403-79-3
Molecular Formula	C14H15FO5
Molecular Weight	282.26 g/mol
Synonyms	Diethyl (4-fluorobenzoyl)propanedioate; Propanedioic acid, (4-fluorobenzoyl)-, diethyl ester; 4-Fluorobenzoylmalonic Acid Diethyl Ester; Diethyl 4-Fluorobenzoylmalonate; (4-Fluorobenzoyl)malonic Acid Diethyl Ester; Ethyl (4-fluorobenzoyl)malonate; 174403-79-3 (CAS)
EINECS	Contact for details

Quality Control

Our Diethyl (4-Fluorobenzoyl)Malonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, verified by advanced analytical techniques including HPLC, GC, and NMR. We adhere to cGMP principles where applicable, and our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98.0% - 99.5%)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.