Description

5,7-Difluoro-2,3-Dihydro-1H-Inden-1-Ol is a fluorinated indanol derivative, a versatile chiral building block and intermediate prized for its unique molecular scaffold. This compound matters for its role in the synthesis of complex molecules, particularly in pharmaceutical research where the introduction of fluorine atoms can dramatically alter a drug candidate's metabolic stability, bioavailability, and binding affinity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and pesticides where the difluoro-substituted indane core contributes to biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and advanced polymers due to its rigid, fluorinated aromatic structure.
• Chemical Biology Probes: Utilized as a scaffold for designing molecular probes and inhibitors to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences industry with bespoke fluorinated compounds.

Basic Information

Product Name	5,7-Difluoro-2,3-Dihydro-1H-Inden-1-Ol
CAS No.	173996-15-1
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	5,7-Difluoro-1-indanol; 5,7-Difluoro-2,3-dihydro-1H-inden-1-ol; 1H-Inden-1-ol, 5,7-difluoro-2,3-dihydro-; 5,7-Difluoroindan-1-ol; (±)-5,7-Difluoro-2,3-dihydro-1H-inden-1-ol; 5,7-Difluoro-1-hydroxyindane; 173996-15-1; 5,7-Difluoroindanol
EINECS	Contact for details

Quality Control

Our 5,7-Difluoro-2,3-Dihydro-1H-Inden-1-Ol is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We can support development with custom purity grades, from technical to high-purity research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified for high-purity grades. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Chiral Purity	Contact for details (Racemic standard)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.