Description

n-Despropyl Ropinirole Hydrochloride is a key pharmaceutical intermediate and reference standard of significant importance in modern drug development and quality control. This compound is primarily valued for its role in the synthesis and analytical characterization of Ropinirole, a widely prescribed medication for Parkinson's disease and Restless Legs Syndrome. It is an essential material for pharmaceutical R&D laboratories, quality assurance departments, and manufacturers engaged in the production of high-purity active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthetic pathway for the production of Ropinirole Hydrochloride API.
• Analytical Reference Standard: Used as a high-purity standard in HPLC, LC-MS, and other chromatographic methods for method development, validation, and impurity profiling.
• Metabolite Studies: Employed in pharmacokinetic and drug metabolism research to study the biotransformation pathways of Ropinirole.
• Process Development & Optimization: Serves as a key reagent for optimizing synthetic routes and scaling up manufacturing processes in pharmaceutical chemistry.
• Impurity Synthesis and Control: Utilized to synthesize and qualify specified impurities or degradation products for regulatory filings (e.g., ICH guidelines).
• Academic and Contract Research: A valuable compound for pharmacological and chemical research in academic institutions and CROs (Contract Research Organizations).

Basic Information

Product Name	n-Despropyl Ropinirole Hydrochloride
CAS No.	173990-76-6
Molecular Formula	C13H17N3O • HCl
Molecular Weight	267.76 g/mol
Synonyms	4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one Hydrochloride (Despropyl); Ropinirole Despropyl Impurity; Ropinirole Related Compound A; SKF-101468-A; 2H-Indol-2-one, 1,3-dihydro-4-[2-(dipropylamino)ethyl]-, hydrochloride (1:1); Despropyl Ropinirole HCl; Ropinirole N-Despropyl Impurity.
EINECS	Contact for details

Quality Control

Our n-Despropyl Ropinirole Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D and manufacturing. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, supporting compliance with ICH Q3A/B and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.