Description

Fmoc-L-4-Cyanophenylalanine CAS NO 173963-93-4 is a protected, non-natural amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound is a critical building block for introducing the unique 4-cyanophenylalanine side chain, which is valuable for studying protein structure, function, and interactions. It is primarily used by research institutions, pharmaceutical developers, and biotechnology companies engaged in advanced peptide chemistry, medicinal chemistry, and the development of novel therapeutics and diagnostic probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated synthesis of custom peptides.
• Medicinal Chemistry & Drug Discovery: Used to incorporate a cyano-functionalized aromatic side chain into peptide-based drug candidates to modulate bioavailability, binding affinity, and metabolic stability.
• Bioconjugation & Probe Development: The cyano group serves as a chemical handle for further modification via click chemistry or other bioorthogonal reactions, enabling the creation of fluorescent or affinity-labeled peptides.
• Structural Biology Studies: Incorporation of this non-natural amino acid into proteins allows researchers to probe local electronic environments, study protein folding, and investigate protein-ligand interactions using techniques like infrared spectroscopy.
• Peptide Library Construction: A key component in the synthesis of diverse peptide libraries for high-throughput screening against biological targets.
• Material Science & Biomaterials: Used in the design of functional peptides for creating smart surfaces, hydrogels, and other advanced biomaterials.

Basic Information

Product Name	Fmoc-L-4-Cyanophenylalanine
CAS No.	173963-93-4
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-Phe(4-CN)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-cyano-L-phenylalanine; Fmoc-4-Cyano-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(4-cyanophenyl)propanoic acid; Fmoc-L-Phe(4-CN)-OH; N-Fmoc-4-cyano-L-phenylalanine; Fmoc-4-CN-Phe-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-4-Cyanophenylalanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) detailing purity, identity, and specific impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.