Description

Ac-Dl-Phe(4-Cn)-Oet is a synthetic, non-natural amino acid derivative featuring a cyano group at the para-position of the phenylalanine side chain. This modified amino acid building block is crucial for advanced peptide synthesis and medicinal chemistry research, enabling the exploration of novel bioactive compounds with tailored properties. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on developing peptide-based therapeutics, enzyme inhibitors, and chemical probes.

Application

• Peptide Synthesis Building Block: Used as a key intermediate in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methods to incorporate a cyano-substituted phenylalanine residue into peptide sequences.
• Medicinal Chemistry & Drug Discovery: Serves as a critical scaffold for designing and synthesizing novel peptide mimetics, protease inhibitors, and receptor ligands, leveraging the electron-withdrawing cyano group for structure-activity relationship (SAR) studies.
• Biochemical Research: Employed in the study of enzyme-substrate interactions and protein engineering, where the modified side chain can act as a spectroscopic probe or alter binding affinity.
• Chemical Biology Tool Development: Utilized to create activity-based probes (ABPs) or photoaffinity labels for target identification and validation in complex biological systems.
• Material Science Applications: Can be incorporated into specialty polymers or surface coatings to impart specific chemical functionalities derived from the cyano group.

Basic Information

Item	Details
Product Name	Ac-Dl-Phe(4-Cn)-Oet
CAS No.	173963-92-3
Molecular Formula	C14H16N2O3
Molecular Weight	260.29 g/mol
Synonyms	Acetyl-DL-phenylalanine(4-cyano)-ethyl ester; N-Acetyl-4-cyano-DL-phenylalanine ethyl ester; Ethyl N-acetyl-4-cyano-DL-phenylalaninate; Ac-DL-Phe(4-CN)-OEt; DL-4-Cyanophenylalanine N-acetyl ethyl ester; N-Acetyl-DL-4-cyanophenylalanine ethyl ester; Ac-4-CN-DL-Phe-OEt
EINECS	Contact for details

Quality Control

Our Ac-Dl-Phe(4-Cn)-Oet is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify the racemic mixture. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Racemic mixture (DL)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.