Description

3-(4-(Trifluoromethyl)Phenyl)Prop-2-Yn-1-Ol CAS NO 173546-21-9 is a specialized organic building block featuring a terminal alkyne and a trifluoromethylphenyl group. This unique structure makes it a valuable intermediate for synthesizing more complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working in medicinal chemistry and material science. Its utility stems from the reactivity of the alkyne group for click chemistry and coupling reactions, combined with the desirable properties imparted by the trifluoromethyl moiety.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the CF3 group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Click Chemistry: The terminal alkyne is ideal for Huisgen 1,3-dipolar cycloaddition reactions with azides, a cornerstone of bioconjugation and labeling strategies.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) in fluorine-containing molecules.

Basic Information

Product Name	3-(4-(Trifluoromethyl)Phenyl)Prop-2-Yn-1-Ol
CAS No.	173546-21-9
Molecular Formula	C10H7F3O
Molecular Weight	200.16 g/mol
Synonyms	4-(Trifluoromethyl)phenylpropargyl alcohol; 3-[4-(Trifluoromethyl)phenyl]prop-2-yn-1-ol; 1-(Trifluoromethyl)-4-(2-hydroxyethynyl)benzene; 4-(Trifluoromethyl)phenylacetylene methanol; 2-Propyn-1-ol, 3-[4-(trifluoromethyl)phenyl]-; α-(Trifluoromethyl)phenylpropargyl alcohol; Propargyl alcohol, 4-(trifluoromethyl)phenyl-
EINECS	Contact for details

Quality Control

Our 3-(4-(Trifluoromethyl)Phenyl)Prop-2-Yn-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality ensures reliable performance in your most sensitive synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.