Description

A2E CAS NO 173449-96-2 is a bis-retinoid pyridinium compound, recognized as a major fluorophore of lipofuscin in the retinal pigment epithelium. Its significance lies in its role as a critical biomarker for studying the pathogenesis of age-related macular degeneration (AMD) and Stargardt disease. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and ophthalmic diagnostic sectors who require high-purity reference standards for analytical research and drug discovery.

Application

• Ophthalmic Research: Primary reference standard for the study of lipofuscinogenesis and retinal degeneration mechanisms.
• Drug Discovery & Development: Key target molecule for screening and validating therapeutic agents aimed at treating AMD and Stargardt disease.
• Biomarker Analysis: Used in the development and validation of analytical methods (HPLC, LC-MS) for quantifying A2E levels in biological samples.
• In Vitro Toxicology: Employed in cell-based assays to model and study photoreceptor cell apoptosis and oxidative stress.
• Diagnostic Kit Development: Serves as a critical component in calibrating diagnostic tools for retinal diseases.
• Academic & Institutional Research: Fundamental reagent for investigating the biochemistry of the visual cycle and aging in the eye.

Basic Information

Product Name	A2E
CAS No.	173449-96-2
Molecular Formula	C42H58NO
Molecular Weight	592.92 g/mol
Synonyms	N-retinylidene-N-retinylethanolamine; A2-E; Bisretinoid A2E; A2E bisretinoid; 2-[2,6-Dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E,7E-octatetraen-1-yl]-1-[2,6-dimethyl-8-(2,6,6-trimethyl-1-cyclohexen-1-yl)-1E,3E,5E,7E-octatetraen-1-yl]-4-[hydroxy(pyridin-3-yl)methyl]pyridin-1-ium
EINECS	Contact for details

Quality Control

Our A2E is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to ISO 9001 standards, and our quality systems support the needs of GMP-compliant research environments. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, solutions should be prepared in anhydrous solvents and kept sealed under inert gas. Allow the product to warm to room temperature in the sealed container before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid or viscous oil
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, ethanol, chloroform; insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.