Description

(2-(2-(2-((2-Bromoacetyl)Amino)Ethoxy)Ethoxy)Ethoxy)Acetic Acid is a specialized bifunctional linker molecule featuring a bromoacetyl group and a carboxylic acid, connected by a hydrophilic tetraethylene glycol spacer. This compound matters for its precise reactivity, enabling controlled conjugation and bioconjugation strategies in advanced research and development. It is primarily needed by pharmaceutical researchers, biotech companies, and material scientists working on antibody-drug conjugates (ADCs), peptide synthesis, surface functionalization, and the development of novel diagnostic probes.

Application

• Bioconjugation Reagent: A key intermediate for site-specific modification of proteins, peptides, and antibodies, particularly in ADC (Antibody-Drug Conjugate) development.
• Crosslinking Agent: Used to create stable covalent bonds between biomolecules and surfaces, nanoparticles, or other polymers for diagnostic and therapeutic platforms.
• Polymer Chemistry: Serves as a functional monomer or initiator for synthesizing smart polymers and hydrogels with tailored biorecognition properties.
• Proteomics Research: Employed in activity-based protein profiling (ABPP) and chemical proteomics to label and study enzyme active sites.
• Diagnostic Assay Development: Facilitates the immobilization of capture molecules (e.g., antibodies, antigens) onto biosensor chips and microplates.
• Material Surface Functionalization: Used to introduce reactive carboxylic acid groups onto materials for subsequent biomolecule attachment.
• Peptide Synthesis: Acts as a building block for incorporating PEGylated linkers into synthetic peptide sequences to enhance solubility and pharmacokinetics.
• Ligand Synthesis: A precursor for creating targeted ligands for drug delivery systems and molecular imaging agents.

Basic Information

Product Name	(2-(2-(2-((2-Bromoacetyl)Amino)Ethoxy)Ethoxy)Ethoxy)Acetic Acid
CAS No.	173323-22-3
Molecular Formula	C₁₂H₂₀BrNO₇
Molecular Weight	370.20 g/mol
Synonyms	Bromo-PEG4-acid; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-bromo-2-oxo-; 13-Bromo-2-oxo-2,5,8,11-tetraoxatetradecan-14-oic acid; Bromoacetyl-PEG4-acid; N-(2-(2-(2-(2-Carboxyethoxy)ethoxy)ethoxy)ethyl)-2-bromoacetamide; Bromo-PEG4-COOH; α-Bromoacetamido tetraethylene glycol acetic acid; Bromoacetyl tetraethylene glycol acetic acid
EINECS	Contact for details

Quality Control

Our (2-(2-(2-((2-Bromoacetyl)Amino)Ethoxy)Ethoxy)Ethoxy)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.