Description

Dihydronaftazone o-β-D-Glucuronide is a glucuronide conjugate metabolite of dihydronaftazone, a key compound in pharmaceutical research and development. This high-purity reference standard is critical for analytical method development, pharmacokinetic studies, and metabolic profiling. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug metabolism and safety (ADME/Tox) studies, as well as in the production of calibration standards for bioanalytical assays.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of dihydronaftazone and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for in vitro and in vivo studies to understand the metabolic pathway, clearance, and bioavailability of parent drug compounds.
• Bioanalytical Method Development: Used as a critical component in developing and validating sensitive HPLC-MS/MS or LC-UV methods for preclinical and clinical trials.
• Toxicology & Safety Assessment: Employed in metabolite identification and safety studies to assess the potential toxicity of drug metabolites.
• Quality Control in Manufacturing: Acts as a system suitability standard in the quality control laboratories of API manufacturers to ensure process consistency.
• Academic & Institutional Research: Supports fundamental research in medicinal chemistry, enzymology (specifically glucuronidation), and biochemical pathways.

Basic Information

Product Name	Dihydronaftazone o-β-D-Glucuronide
CAS No.	173321-33-0
Molecular Formula	C₂₀H₂₄N₂O₉
Molecular Weight	436.41 g/mol
Synonyms	Dihydronaftazone Glucuronide; Dihydronaftazone O-β-D-Glucuronide; 4-(3-Methyl-5-oxo-2-pyrazolin-1-yl)-1-naphthyl β-D-Glucopyranosiduronic Acid; 1-[4-(β-D-Glucopyranuronosyloxy)-1-naphthyl]-3-methyl-5-pyrazolone; Naftazone metabolite glucuronide; 1-(4-((β-D-Glucopyranosyluronic acid)oxy)-1-naphthyl)-3-methyl-5-pyrazolone
EINECS	Contact for details

Quality Control

Our Dihydronaftazone o-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring compliance with the stringent requirements for pharmaceutical reference standards. Our quality commitment supports applications in GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.