Description

Buforin II is a potent antimicrobial peptide (AMP) derived from the skin of the Asian toad, *Bufo bufo gargarizans*. This compound is of significant interest for its broad-spectrum activity against bacteria, fungi, and even some cancer cells, with a unique mechanism of action that involves crossing cell membranes without causing lysis. It is primarily utilized in advanced biomedical research, pharmaceutical development, and as a model compound for studying novel antibiotic mechanisms and peptide-based therapeutics.

Application

• Antimicrobial Agent Research: As a model peptide for studying non-lytic mechanisms of action against multidrug-resistant bacteria and fungi.
• Pharmaceutical Development: Investigated as a lead compound for novel antibiotic and antifungal drug candidates.
• Cancer Research: Studied for its potential anticancer properties and selective cytotoxicity against certain tumor cell lines.
• Biomaterial Coating: Research into surface functionalization for developing antimicrobial medical devices and implants.
• Peptide Engineering: Used as a structural template for designing synthetic analogs with enhanced stability and activity.
• Veterinary Medicine: Exploration of applications in treating bacterial infections in animals.

Basic Information

Product Name	Buforin II
CAS No.	172998-24-2
Molecular Formula	C95H153N39O26
Molecular Weight	2260.5 g/mol
Synonyms	Buforin 2; Buforin-2; BUF-II; Antimicrobial Peptide Buforin II; BFP; Bufonin II; Truncated Buforin II; H-Arg-Gln-Arg-Val-Arg-Ile-Gly-Gly-Lys-Arg-Ile-Lys-Val-Gly-Arg-Arg-Leu-Leu-NH2
EINECS	Contact for details

Quality Control

Our Buforin II is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and bioactivity data. We support compliance with relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant or under an inert atmosphere. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10%
Biological Activity (MIC Assay)	Reported per COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.