Description

1-Bromo-4-Chloro-2,5-Difluorobenzene is a high-purity halogenated benzene derivative, serving as a critical multi-functional building block in advanced organic synthesis. Its precise substitution pattern makes it an indispensable intermediate for constructing complex molecules where specific halogen atoms are required for subsequent coupling or substitution reactions. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors for developing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated aromatic rings.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the halogen atoms enable further functionalization.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions due to the presence of bromine and chlorine leaving groups.
• Polymer Chemistry: Employed as a monomer or modifier in the production of high-performance, halogenated engineering plastics and resins.
• Chemical Research & Development: A versatile reagent for exploring new synthetic pathways and creating novel chemical entities in academic and industrial R&D labs.

Basic Information

Product Name	1-Bromo-4-Chloro-2,5-Difluorobenzene
CAS No.	172921-33-4
Molecular Formula	C6H2BrClF2
Molecular Weight	227.44 g/mol
Synonyms	4-Bromo-1-Chloro-2,5-Difluorobenzene; 2,5-Difluoro-4-bromo-1-chlorobenzene; 1-Chloro-4-bromo-2,5-difluorobenzene; Benzene, 1-bromo-4-chloro-2,5-difluoro-; 2,5-Difluorophenyl-1,4-dihalide (mixed); 4-Bromo-2,5-difluorochlorobenzene; 1,4-Dihalo-2,5-difluorobenzene (mixed)
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Chloro-2,5-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to guarantee consistent quality and traceability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	45 - 50 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.