Description

2,5-Difluoro-4-Nitrobenzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its value lies in the strategic positioning of its electron-withdrawing nitro and nitrile groups, which activate the aromatic ring for nucleophilic substitution, making it a key precursor for complex heterocyclic systems. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of specialty dyes, pigments, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated heterocycles like pyridines, pyrimidines, and quinolines.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science: Serves as a monomer or precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye & Pigment Manufacturing: Employed in the synthesis of complex, high-performance dyes and pigments due to its ability to modify color properties and lightfastness.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures common in many functional molecules.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	2,5-Difluoro-4-Nitrobenzonitrile
CAS No.	172921-32-3
Molecular Formula	C7H2F2N2O2
Molecular Weight	184.10 g/mol
Synonyms	4-Nitro-2,5-difluorobenzonitrile; 2,5-Difluoro-4-nitrobenzenecarbonitrile; Benzonitrile, 2,5-difluoro-4-nitro-; 2,5-Difluoro-4-nitro-benzonitrile; 172921-32-3; 2,5-Difluoro-4-nitrobenzonitrile; 4-Cyano-2,5-difluoronitrobenzene
EINECS	Contact for details

Quality Control

Our 2,5-Difluoro-4-Nitrobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.