Description

Human PTHrP-(1-36) is a synthetic 36-amino acid peptide fragment of the larger parathyroid hormone-related protein (PTHrP). This biologically active sequence is crucial for research into calcium metabolism, bone physiology, and related endocrine pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on metabolic bone disorders and cancer research.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of PTH/PTHrP receptor signaling, bone formation, and resorption.
• Drug Discovery & Development: Serves as a key tool compound for screening and developing therapeutics targeting osteoporosis, hypercalcemia of malignancy, and other bone-related conditions.
• Diagnostic Assay Development: Employed in the calibration and validation of immunoassays (e.g., ELISA) designed to measure PTHrP levels in clinical samples.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to investigate the effects of PTHrP on osteoblast, osteoclast, and chondrocyte activity.
• Academic & Institutional Research: Fundamental research tool for understanding the physiological and pathological roles of PTHrP in development and disease.

Basic Information

Product Name	Human PTHrP-(1-36)
CAS No.	172867-62-8
Molecular Formula	C181H291N55O51S2
Molecular Weight	4108.8 g/mol
Synonyms	Parathyroid Hormone-Related Protein (1-36); PTHrP (1-36); PTHLH (1-36); hPTHrP(1-36); Parathyroid hormone-like protein (1-36); Hypercalcemia of malignancy factor (1-36); PTH-related peptide fragment 1-36; PLP (1-36)
EINECS	Contact for details

Quality Control

Our Human PTHrP-(1-36) is manufactured under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to GMP principles for peptide synthesis, and specifications are designed to meet the rigorous demands of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Conforms to theoretical composition
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Determined by in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.