Description

Fmoc-D-Leu-Ome CAS NO 172846-55-8 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound serves as a critical chiral building block, enabling the controlled and efficient incorporation of D-leucine into complex peptide sequences. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require reliable, high-quality intermediates for the development of novel therapeutic peptides, peptidomimetics, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the automated, sequential assembly of custom peptides using Fmoc-chemistry protocols.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation & Probe Development: Acts as a precursor for creating labeled peptides or peptide conjugates for diagnostic and imaging applications.
• Academic & Industrial Research: Employed in biochemical studies to investigate protein-protein interactions, enzyme specificity, and structure-activity relationships (SAR).
• Production of Peptidomimetics: Facilitates the synthesis of modified peptide analogs with enhanced stability, bioavailability, or biological activity.
• Combinatorial Chemistry Libraries: Serves as a valuable component for generating diverse peptide libraries used in high-throughput screening for drug discovery.

Basic Information

Product Name	Fmoc-D-Leu-Ome
CAS No.	172846-55-8
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-D-leucine methyl ester; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-methylpentanoic acid methyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-leucine methyl ester; FMOC-D-LEU-OME; Methyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-leucinate; D-Leucine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-D-Leu-Ome is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes to ensure compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Melting Point	Contact for details
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.