Description

2'-C-Methyl-6-S-Methyl-6-Thio-Inosine is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a crucial building block and intermediate in the synthesis of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the development of nucleoside-based drugs targeting viral polymerases and other key enzymes. The compound's unique thio-substituted structure offers a pathway to modulate biological activity and metabolic stability in drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of antiviral medications, particularly for Hepatitis C Virus (HCV) and other RNA viruses.
• Antiviral Drug Development: Used in the synthesis of nucleoside polymerase inhibitors, where its modified ribose and base structure is critical for biological activity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand polymerase mechanisms and nucleotide metabolism.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of new drug entities.
• Process Chemistry & Scale-Up: Used in the development and optimization of large-scale synthetic routes for active pharmaceutical ingredients (APIs).
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	2'-C-Methyl-6-S-Methyl-6-Thio-Inosine
CAS No.	172722-76-8
Molecular Formula	C12H16N4O5S
Molecular Weight	328.34 g/mol
Synonyms	6-(Methylthio)-2'-C-methylinosine; 2'-C-Methyl-6-methylmercaptoinosine; 2'-C-Methyl-6-methylthioinosine; 6-Methylthio-2'-C-methylinosine; 2'-Methyl-6-(methylthio)inosine; 2'-C-Methyl-6-(methylthio)-9H-purin-9-yl-β-D-ribofuranoside; 6-Methylsulfanyl-2'-C-methyl-inosine; INX-08144 (development code intermediate)
EINECS	Contact for details

Quality Control

Our 2'-C-Methyl-6-S-Methyl-6-Thio-Inosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical R&D and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.