Description

Mmp-1/Mmp-9 Substrate, Fluorogenic CAS NO 172702-58-8 is a specialized, high-purity peptide-based fluorogenic substrate designed for the sensitive and selective detection of matrix metalloproteinase-1 (MMP-1, Collagenase-1) and MMP-9 (Gelatinase B) activity. This compound is critical for enabling precise biochemical and cell-based assays in drug discovery and basic research, where accurate enzyme kinetics and inhibition profiling are paramount. It is an essential reagent for pharmaceutical R&D teams, academic researchers, and diagnostic developers focused on oncology, inflammation, and tissue remodeling studies.

Application

• High-Throughput Screening (HTS) for MMP-1 and MMP-9 inhibitor discovery in drug development pipelines.
• Enzyme Kinetic Studies to determine kinetic parameters (Km, Vmax, kcat) and characterize novel enzyme variants.
• Cell-Based Assays for monitoring real-time MMP activity in live cells, including cancer cell invasion and migration studies.
• Biochemical Profiling of recombinant MMP enzymes for purity, activity, and specificity validation.
• Diagnostic Research for developing assays to detect MMP activity in biological samples (e.g., serum, tissue lysates).
• Academic Research in fields of cancer biology, arthritis, cardiovascular disease, and wound healing.

Basic Information

Product Name	Mmp-1/Mmp-9 Substrate, Fluorogenic
CAS No.	172702-58-8
Molecular Formula	C34H46F3N7O9
Molecular Weight	753.77 g/mol
Synonyms	MMP-1/MMP-9 Fluorogenic Substrate; Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2; (7-Methoxycoumarin-4-yl)acetyl-Pro-Leu-Gly-Leu-N3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl-Ala-Arg-NH2; Fluorogenic Peptide Substrate for MMP-1 and MMP-9; Dnp-Peptide Substrate; Mca-PLGL-Dpa-AR-NH2; Collagenase-1/Gelatinase B Substrate
EINECS	Contact for details

Quality Control

Our Mmp-1/Mmp-9 Substrate, Fluorogenic is manufactured under strict quality systems to ensure batch-to-batch consistency and performance in sensitive assays. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and functional activity validation against standard MMP enzymes. Certificates of Analysis (COA) detailing purity, identity, and performance data are provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Functional Activity	≥ 90% relative activity vs. control
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.