Description

3-n-Boc-(S)-Amino Butyronitrile is a high-purity, chiral building block of significant importance in advanced organic synthesis. Its core value lies in providing a protected amino nitrile functionality, which is a versatile precursor for the construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), peptidomimetics, and other fine chemicals where stereochemical control is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, enzyme inhibitors, and other bioactive molecules.
• Peptidomimetics & Amino Acid Derivatives: Used to introduce non-natural amino acid backbones and constrained structures into peptide-based drug candidates.
• Asymmetric Synthesis: Serves as a starting material for the preparation of chiral β-amino acids, diamines, and other nitrogen-containing heterocycles.
• Agrochemical Research: Employed in the development of novel, chiral active ingredients with specific biological activity.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in organic chemistry and catalysis.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing targeted compounds at various scales.

Basic Information

Product Name	3-n-Boc-(S)-Amino Butyronitrile
CAS No.	172695-22-6
Molecular Formula	C9H16N2O2
Molecular Weight	184.24 g/mol
Synonyms	(S)-3-((tert-Butoxycarbonyl)amino)butanenitrile; (S)-3-(Boc-amino)butyronitrile; (S)-3-[(tert-Butoxycarbonyl)amino]butyronitrile; tert-Butyl (S)-(1-cyanoethyl)carbamate; (S)-3-(tert-Butoxycarbonylamino)butyronitrile; Boc-(S)-3-aminobutyronitrile; (S)-3-Amino-4-cyanobutanoic acid tert-butyl ester (tautomeric form); (S)-Boc-3-aminobutyronitrile
EINECS	Contact for details

Quality Control

Our 3-n-Boc-(S)-Amino Butyronitrile is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can provide material with specifications tailored to your process requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.