Description

Phosphine, 1,1'-[(1R)-6,6'-Dimethoxy[1,1'-Biphenyl]-2,2'-Diyl]Bis[1,1-Dicyclohexyl- is a specialized chiral phosphine ligand with a complex biphenyl backbone, designed for high-performance catalytic applications. This compound is valued for its ability to impart exceptional enantioselectivity and reactivity in asymmetric synthesis, a critical requirement for producing optically pure intermediates. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical and fine chemical sectors for developing advanced active pharmaceutical ingredients (APIs) and specialty molecules.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical synthesis.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions such as Suzuki-Miyaura and Buchwald-Hartwig amination for constructing complex biaryl and C-N bond structures.
• Asymmetric Allylic Substitution: Facilitates the creation of chiral carbon centers with high enantiomeric excess in advanced synthetic routes.
• Pharmaceutical Intermediate Production: Critical for the synthesis of chiral drug candidates and final APIs requiring high optical purity.
• Catalyst Development & Screening: Used in R&D for discovering and optimizing new catalytic systems for industrial chemical processes.
• Fine Chemical Synthesis: Applied in the manufacture of specialty chemicals, agrochemicals, and flavors & fragrances where stereochemistry is paramount.

Basic Information

Product Name	Phosphine, 1,1'-[(1R)-6,6'-Dimethoxy[1,1'-Biphenyl]-2,2'-Diyl]Bis[1,1-Dicyclohexyl-
CAS No.	172617-14-0
Molecular Formula	C44H60O2P2
Molecular Weight	682.89 g/mol
Synonyms	(R)-6,6'-Dimethoxy-2,2'-bis(dicyclohexylphosphino)biphenyl; (R)-DMCy-BIPHEP; (R)-DMCyBIPHEP; (R)-2,2'-Bis(dicyclohexylphosphino)-6,6'-dimethoxy-1,1'-biphenyl; (R)-(-)-6,6'-Dimethoxy-2,2'-bis(dicyclohexylphosphino)biphenyl; (R)-DMCyBIPHEP Ligand; (R)-DMCy-BIPHEP Phosphine Ligand; BIPHEP Derivative Phosphine Ligand
EINECS	Contact for details

Quality Control

Our high-purity chiral ligands are manufactured under strict quality control protocols to ensure batch-to-batch consistency and performance. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to verify chemical identity, enantiomeric excess (ee), and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This compound is easily oxidized and moisture-sensitive; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (ee)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.