Description

Fmoc-Glu(Odmab)-Oh is a protected amino acid derivative, specifically an Fmoc-glutamic acid with an orthogonally protected side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of glutamic acid into peptide chains using Fmoc-chemistry protocols.
• Pharmaceutical Research: Used in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Bioconjugation: Serves as a precursor for creating peptide-drug conjugates or labeled peptides for diagnostic and therapeutic applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify novel bioactive peptides.
• Biochemical Research: Essential for producing custom peptides used as tools in enzymology, immunology, and cell signaling studies.
• GPCR Ligand Development: Used in the synthesis of peptide hormones and neuropeptides that target G-protein-coupled receptors.

Basic Information

Product Name	Fmoc-Glu(Odmab)-Oh
CAS No.	172611-75-5
Molecular Formula	C₃₀H₃₂N₂O₇
Molecular Weight	532.59 g/mol
Synonyms	Fmoc-Glu(ODmab)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-{[4-(dimethylamino)benzyl]oxy}-L-glutamic acid; Fmoc-L-glutamic acid 4-(4-(dimethylamino)benzyl) ester; Fmoc-Glu(O-Dmab)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-5-{[4-(dimethylamino)benzyl]oxy}-5-oxopentanoic acid; Fmoc-Glu(ODmb)-OH (common abbreviation); L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 4-[4-(dimethylamino)phenyl]methyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Odmab)-Oh is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.