Description

Fmoc-Tyr(Po(Nme2)2)-Oh is a protected, phosphonated tyrosine derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is critical for introducing phosphonated tyrosine residues into peptide sequences, enabling the study of protein phosphorylation and signal transduction pathways. It is an essential building block for researchers and manufacturers in pharmaceutical R&D, particularly for developing therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of phosphopeptides and phosphonate analogs.
• Pharmaceutical Research: Used in the development of peptide-based drugs targeting kinases, phosphatases, and phosphoprotein interactions.
• Biochemical Tool Development: Synthesis of non-hydrolyzable phosphotyrosine mimetics for studying enzyme mechanisms and inhibition.
• Proteomics and Signal Transduction Studies: Incorporation into peptide substrates and inhibitors to investigate phosphorylation-dependent cellular processes.
• Antibody and Diagnostic Reagent Production: Creation of phospho-specific antigens for antibody generation in immunoassay development.

Basic Information

Product Name	Fmoc-Tyr(Po(Nme2)2)-Oh
CAS No.	172611-23-3
Molecular Formula	C29H31N2O7P
Molecular Weight	550.54 g/mol
Synonyms	Fmoc-O-phosphono-N,N-dimethyl-L-tyrosine; Fmoc-L-Tyr(PO(NMe2)2)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-[bis(dimethylamino)phosphinyl]-L-tyrosine; Fmoc-Tyr(PO(ONMe2)2)-OH; Fmoc-Tyr(PO(N(CH3)2)2)-OH; Fmoc-O-(N,N-dimethylphosphoramidate)-L-tyrosine; (2S)-3-(4-{[Bis(dimethylamino)phosphoryl]oxy}phenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Tyr(Po(Nme2)2)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity by HPLC, identity confirmation, and impurity profiles. We adhere to cGMP guidelines where applicable to support our customers' regulatory requirements in drug development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.