Description

Fmoc-1-Amino-4,7,10-Trioxa-13-Tridecanamine Succinimic Acid is a specialized, heterobifunctional polyethylene glycol (PEG)-based linker molecule designed for advanced bioconjugation and peptide synthesis. This compound matters because it provides a versatile platform for creating stable, water-soluble conjugates, bridging biomolecules with other entities like drugs, dyes, or solid supports. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic reagent production who require precise and reliable cross-linking strategies.

Application

• Solid-Phase Peptide Synthesis (SPPS): Acts as a hydrophilic, flexible spacer for introducing Fmoc-protected amino groups into peptide chains, enhancing solubility and bioactivity.
• Bioconjugation and ADC Development: Serves as a critical linker for antibody-drug conjugates (ADCs), connecting cytotoxic payloads to antibodies via its amine-reactive succinimidyl ester and Fmoc-protected amine.
• PEGylation Reagent: Used to PEGylate proteins, peptides, and small molecules to improve pharmacokinetic properties such as solubility, stability, and circulation half-life.
• Surface Functionalization: Employed to modify nanoparticles, biosensors, and microarray surfaces with amine-reactive groups for subsequent biomolecule immobilization.
• Cross-linking Agent: Facilitates the formation of stable amide bonds between amine-containing molecules in aqueous buffer conditions.
• Prodrug Synthesis: Utilized in the design of prodrugs where a therapeutic agent is linked via a cleavable PEG spacer for controlled release.

Basic Information

Item	Detail
Product Name	Fmoc-1-Amino-4,7,10-Trioxa-13-Tridecanamine Succinimic Acid
CAS No.	172089-14-4
Molecular Formula	C28H42N2O10
Molecular Weight	566.65 g/mol
Synonyms	Fmoc-NH-PEG3-NHS ester; Fmoc-15-amino-4,7,10,13-tetraoxapentadecanoic acid succinimidyl ester; Nα-Fmoc-Nε-(3-maleimidopropionyl)-L-lysine; Fmoc-PEG3-NHS; 1-Amino-4,7,10-trioxa-13-tridecanamine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, N-succinimidyl ester; Fmoc-N-amido-PEG3-acid NHS ester; Fmoc-NH-(CH2CH2O)3-CH2CH2-NH-CO-(CH2)2-CO-ONSu
EINECS	Contact for details

Quality Control

Our Fmoc-1-Amino-4,7,10-Trioxa-13-Tridecanamine Succinimic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive applications like bioconjugation and peptide synthesis. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and the active ester is susceptible to hydrolysis. For long-term stability, store in aliquots to avoid repeated freeze-thaw cycles. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.