Description

Boc-Dab(Aloc)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced peptide synthesis. This compound matters for its critical role in facilitating complex, multi-step solid-phase and solution-phase peptide assembly, particularly for sequences requiring selective deprotection strategies. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel therapeutic peptides, peptidomimetics, and as a key building block in medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial Fmoc- or Boc-strategy building block for incorporating the diaminobutyric acid (Dab) residue with orthogonal side-chain protection.
• Solution-Phase Peptide Synthesis: Enables the controlled, sequential coupling in complex peptide chain elongation in solution.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide-based pharmaceuticals, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Peptidomimetic Design: Acts as a precursor for creating modified peptide structures with enhanced stability, bioavailability, or receptor affinity.
• Bioconjugation: Facilitates the site-specific attachment of peptides to other molecules, surfaces, or carriers via the selectively removable Aloc (Alloc) protecting group.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive peptide leads.

Basic Information

Item	Details
Product Name	Boc-Dab(Aloc)-Oh
CAS No.	171820-73-8
Molecular Formula	C13H22N2O6
Molecular Weight	302.33 g/mol
Synonyms	N-α-Boc-N-γ-Alloc-L-2,4-diaminobutyric acid; Boc-L-Dab(Alloc)-OH; (S)-2-((tert-Butoxycarbonyl)amino)-4-((allyloxy)carbonyl)amino)butanoic acid; Boc-Dab(Alloc)-OH; tert-Butyl (S)-(1-((allyloxy)carbonyl)amino)-4-carboxy-3-butyl)carbamate; N-Boc-N'-Alloc-L-diaminobutyric acid; Boc-Dab(Alloc)-OH CAS 171820-73-8; L-Dab(Boc,Alloc)-OH
EINECS	Contact for details

Quality Control

Our Boc-Dab(Aloc)-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and correct stereochemical integrity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.