Description

(S)-1-(Dicyclohexylphosphino)-2-[(R)-1-(Dimethylamino)Ethyl]Ferrocene is a chiral, ferrocene-based phosphine ligand, a critical component in asymmetric catalysis. Its unique three-dimensional structure provides excellent stereocontrol in transition metal-catalyzed reactions, enabling the synthesis of high-value enantiomerically pure compounds. This ligand is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries who require high enantioselectivity and yield in cross-coupling, hydrogenation, and other key transformations.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines to produce chiral intermediates for active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Employed in asymmetric Suzuki-Miyaura, Negishi, and Buchwald-Hartwig amination reactions to construct chiral biaryl and C-N bonds.
• Pharmaceutical Intermediate Synthesis: Critical for the production of enantiomerically pure drug candidates and chiral building blocks in process chemistry.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and pesticides to enhance efficacy and reduce environmental impact.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new asymmetric catalytic processes in laboratory settings.
• Fine Chemical Production: Facilitates the manufacture of specialty chemicals, flavors, and fragrances requiring high optical purity.

Basic Information

Product Name	(S)-1-(Dicyclohexylphosphino)-2-[(R)-1-(Dimethylamino)Ethyl]Ferrocene
CAS No.	171817-39-3
Molecular Formula	C26H40FeNP
Molecular Weight	453.43 g/mol
Synonyms	(S,R)-JOSIPHOS; (S)-1-[(R)-2-(Dimethylamino)ethyl]ferrocenyl-dicyclohexylphosphine; Josiphos SL-J009-1; (S)-1-[(R)-2-(N,N-Dimethylamino)ethyl]ferrocenyldicyclohexylphosphine; (S)-1-[(R)-1-(Dimethylamino)ethyl]-2-(dicyclohexylphosphino)ferrocene; (S,R)-JOSIPHOS ligand; (S,R)-PPF-PCy2; (S,R)-Josiphos ligand
EINECS	Contact for details

Quality Control

Our (S)-1-(Dicyclohexylphosphino)-2-[(R)-1-(Dimethylamino)Ethyl]Ferrocene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP and ISO compliant workflows in advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.