Description

(S)-1-Cbz-5-Oxopyrrolidine-2-Carboxamide is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters as a key building block for the development of novel pharmaceuticals, particularly in the creation of peptidomimetics and protease inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new drug candidates, especially for neurological and metabolic disorders.
• Peptidomimetic Synthesis: Serves as a proline-like scaffold for constructing molecules that mimic peptide structure and function, enhancing metabolic stability.
• Protease Inhibitor Development: Used in the synthesis of potential inhibitors for various enzymes like DPP-4, crucial in diabetes and antiviral research.
• Asymmetric Synthesis: Employed in stereoselective reactions to introduce the (S)-configured pyrrolidinone moiety into more complex molecular architectures.
• Chemical Biology Research: Utilized as a tool compound or a precursor for labeled probes in studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A requested intermediate for custom synthesis services catering to the pharmaceutical and biotechnology sectors.

Basic Information

Product Name	(S)-1-Cbz-5-Oxopyrrolidine-2-Carboxamide
CAS No.	171738-41-3
Molecular Formula	C13H14N2O4
Molecular Weight	262.26 g/mol
Synonyms	(S)-1-[(Benzyloxy)carbonyl]-5-oxopyrrolidine-2-carboxamide; (S)-1-Carbobenzoxy-5-oxopyrrolidine-2-carboxamide; (S)-N-Cbz-5-oxopyrrolidine-2-carboxamide; (S)-1-Cbz-pyroglutamine; (S)-1-(Benzyloxycarbonyl)-2-pyrrolidone-5-carboxamide; (S)-5-Oxo-1-[(phenylmethoxy)carbonyl]-2-pyrrolidinecarboxamide; (S)-Pyroglutamic acid Cbz-amide; (S)-1-Cbz-5-oxo-proline amide
EINECS	Contact for details

Quality Control

Our (S)-1-Cbz-5-Oxopyrrolidine-2-Carboxamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP starting material applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged operations to ensure stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.