Description

Cyclobutanecarboxamide, 3-Amino-N-Methoxy-N-Methyl-, trans- (9Ci) is a specialized chiral amine derivative featuring a cyclobutane ring, a key structural motif in advanced pharmaceutical synthesis. This compound is valued for its role as a sophisticated building block or chiral intermediate in the development of novel active pharmaceutical ingredients (APIs). It is primarily targeted at pharmaceutical R&D and fine chemical synthesis teams working on complex, stereochemically defined molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) or metabolic disorder targets.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry: Serves as a core scaffold or a functionalized fragment for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Peptidomimetics Research: The trans-cyclobutane carboxamide structure can be incorporated into peptide analogs to enhance metabolic stability and conformational rigidity.
• Agrochemical Synthesis: Potential intermediate in the synthesis of advanced, high-efficacy crop protection agents requiring specific stereochemistry.
• Ligand and Catalyst Development: Can be functionalized to create novel chiral ligands for metal-catalyzed transformations in fine chemical manufacturing.

Basic Information

Product Name	Cyclobutanecarboxamide, 3-Amino-N-Methoxy-N-Methyl-, trans- (9Ci)
CAS No.	171549-88-5
Molecular Formula	C7H14N2O2
Molecular Weight	158.20 g/mol
Synonyms	trans-3-Amino-N-methoxy-N-methylcyclobutanecarboxamide; (1R,3S)-3-Amino-N-methoxy-N-methylcyclobutanecarboxamide; (1S,3R)-3-Amino-N-methoxy-N-methylcyclobutanecarboxamide; N-Methoxy-N-methyl-trans-3-aminocyclobutanecarboxamide; trans-3-Amino-N-methoxy-N-methyl-1-cyclobutanecarboxamide; 3-Amino-N-methoxy-N-methylcyclobutanecarboxamide, trans-; A Building Block for AMG 837 Synthesis
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical intermediates are manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity (enantiomeric excess), to ensure compliance with research and development specifications. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e. (trans-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.