Description

Cyclobutanecarboxamide, 3-Hydroxy-n-Methoxy-n-Methyl-, trans- (9Ci) is a high-purity, specialized organic compound featuring a functionalized cyclobutane ring system. This molecule matters as a valuable chiral building block and intermediate for the synthesis of complex pharmaceuticals and advanced materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Agrochemical Synthesis: Used in the preparation of novel herbicides and fungicides, leveraging its constrained cyclobutane structure for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance molecules, flavors, and other high-value specialty chemicals.
• Academic & Contract Research: A critical reagent for methodological studies in organic synthesis, including ring-opening and functional group transformation chemistry.
• Material Science Research: Investigated as a monomer or cross-linking agent for producing polymers with unique thermal and mechanical properties.

Basic Information

Product Name	Cyclobutanecarboxamide, 3-Hydroxy-n-Methoxy-n-Methyl-, trans- (9Ci)
CAS No.	171549-82-9
Molecular Formula	C7H13NO3
Molecular Weight	159.18 g/mol
Synonyms	trans-3-Hydroxy-N-methoxy-N-methylcyclobutanecarboxamide; (1r,3r)-3-Hydroxy-N-methoxy-N-methylcyclobutanecarboxamide; N-Methoxy-N-methyl-trans-3-hydroxycyclobutanecarboxamide; trans-N-Methoxy-N-methyl-3-hydroxycyclobutanecarboxamide; Cyclobutanecarboxamide, 3-hydroxy-N-methoxy-N-methyl-, trans-; 3-Hydroxy-N-methoxy-N-methylcyclobutanecarboxamide (trans); Weinhaus Amide (trans-3-hydroxy derivative); A key intermediate for CGRP receptor antagonists
EINECS	Contact for details

Quality Control

Every batch of Cyclobutanecarboxamide, 3-Hydroxy-n-Methoxy-n-Methyl-, trans- (9Ci) is produced under strict quality management protocols. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Comprehensive analytical data, including chiral purity and impurity profiles, are documented. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.