Description

Metoclopramide n-Oxide is a key pharmaceutical intermediate and metabolite of the antiemetic drug metoclopramide. This compound is of significant importance for research and development in pharmacology and analytical chemistry, serving as a critical reference standard. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism studies, impurity profiling, and quality control processes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of metoclopramide and its related substances in drug products and biological samples.
• Metabolite Research: Essential for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and bioavailability of metoclopramide.
• Impurity Profiling: Serves as a known impurity standard in the development and validation of analytical methods (e.g., HPLC, LC-MS) to ensure drug purity and compliance with ICH guidelines.
• Chemical Synthesis: Acts as a building block or precursor in the synthesis of novel chemical entities or for further derivatization in medicinal chemistry programs.
• Quality Control & Assurance: Employed by QA/QC laboratories to calibrate equipment and verify analytical procedures for metoclopramide API and finished dosage forms.

Basic Information

Product Name	Metoclopramide n-Oxide
CAS No.	171367-22-9
Molecular Formula	C14H22ClN3O3
Molecular Weight	315.80 g/mol
Synonyms	Metoclopramide N-Oxide; 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide N-Oxide; Metoclopramide Related Compound C (EP); Metoclopramide Impurity C; 5-Chloro-2-methoxy-4-(methylamino)-N-(2-(diethylamino)ethyl)benzamide 1-Oxide; NSC 351136; AHR-5531C; Reglan Metabolite
EINECS	Contact for details

Quality Control

Our Metoclopramide n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assay by HPLC, and control of specified impurities. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, detailing all test results against relevant pharmacopeial or in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.