Description

Boc-n-Me-D-Thr-Oh CAS NO 170872-87-4 is a protected derivative of the non-proteinogenic amino acid D-threonine, specifically featuring tert-butoxycarbonyl (Boc) and N-methyl (Me) protecting groups. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, enabling precise control over stereochemistry and molecular conformation. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing therapeutic peptides, protease inhibitors, and novel drug candidates where backbone N-methylation is required to enhance metabolic stability and membrane permeability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of N-methylated D-threonine residues.
• Protease Inhibitor Development: Serves as a crucial component in the design and synthesis of selective protease inhibitors for antiviral and anticancer applications.
• Peptidomimetic Research: Enables the creation of stable peptidomimetics with improved pharmacological profiles for drug discovery programs.
• Bioconjugation & Labeling: Can be utilized in the preparation of labeled peptides for diagnostic and research purposes.
• Academic & Industrial R&D: A valuable reagent for chemical biology studies and medicinal chemistry research in academic and corporate laboratories.

Basic Information

Product Name	Boc-n-Me-D-Thr-Oh
CAS No.	170872-87-4
Molecular Formula	C10H19NO5
Molecular Weight	233.26 g/mol
Synonyms	N-[(1,1-Dimethylethoxy)carbonyl]-N-methyl-D-threonine; (2R,3S)-2-[(tert-Butoxycarbonyl)(methyl)amino]-3-hydroxybutanoic acid; Boc-N-Me-D-Thr-OH; Boc-N-Methyl-D-threonine; tert-Butyl N-methyl-N-[(2R,3S)-3-hydroxy-1-oxobutan-2-yl]carbamate; D-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-
EINECS	Contact for details

Quality Control

Our Boc-n-Me-D-Thr-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic methods for structural confirmation, to ensure compliance with high-purity standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and specific impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.