Description

Nociceptin CAS NO 170713-75-4 is a potent endogenous neuropeptide that functions as the natural ligand for the NOP (Nociceptin Opioid Peptide) receptor. This compound is of significant interest for its role in modulating a wide range of physiological processes, including pain perception, anxiety, and reward pathways. It is primarily utilized by researchers and pharmaceutical developers in neuroscience, pharmacology, and drug discovery for studying receptor mechanisms and developing novel therapeutic agents.

Application

• Neuroscience Research: Fundamental studies on pain modulation, anxiety, depression, and addiction mechanisms.
• Pharmacological Profiling: In vitro and in vivo assays to characterize NOP receptor activity and ligand interactions.
• Drug Discovery & Development: A key reference standard and tool compound for screening and developing new analgesics and neuropsychiatric drugs.
• Biochemical Studies: Investigation of G-protein coupled receptor (GPCR) signaling pathways and downstream effects.
• Academic & Institutional Research: Used in university and government labs for grant-funded research on the opioid system.

Basic Information

Product Name	Nociceptin
CAS No.	170713-75-4
Molecular Formula	C₈₄H₁₃₈N₂₄O₂₀
Molecular Weight	1809.2 g/mol
Synonyms	Nociceptin (1-17); N/OFQ; Nociceptin/Orphanin FQ; Orphanin FQ; Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln (sequence); [F/G]FQ (1-17)NH2; NOP receptor agonist; OP4 receptor ligand
EINECS	Contact for details

Quality Control

Our Nociceptin is produced under stringent conditions to ensure the highest standards of purity and biological activity. Each batch undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation. A Certificate of Analysis (COA) detailing purity, peptide content, and solvent residues is provided with every shipment to ensure traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solvent Residues	Meets ICH guidelines
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.