Description

4-Desmethyl-3-Methyl Celecoxib is a key pharmaceutical intermediate and a structural analog of the selective COX-2 inhibitor Celecoxib. This compound is of significant value in the research and development of novel anti-inflammatory and analgesic agents, serving as a crucial building block for medicinal chemistry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of advanced drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of Celecoxib analogs and next-generation COX-2 inhibitors for drug discovery programs.
• Medicinal Chemistry Research: Used as a reference standard and a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Active Pharmaceutical Ingredient (API) Development: Serves as a starting material or an intermediate in the multi-step synthesis of potential API candidates targeting inflammation and pain.
• Biochemical Research: Employed in in-vitro assays to study COX-2 enzyme inhibition mechanisms and related biochemical pathways.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related pharmaceutical compounds.

Basic Information

Product Name	4-Desmethyl-3-Methyl Celecoxib
CAS No.	170570-01-1
Molecular Formula	C16H13F3N2O2S
Molecular Weight	354.35 g/mol
Synonyms	4-Desmethyl-3-Methyl Celecoxib; 4-Desmethyl-3-methylcelecoxib; 4-Hydroxy-3-methylcelecoxib; 3-Methyl-4-hydroxycelecoxib; SC-62807; 1-[4-Methylsulfonylphenyl]-3-trifluoromethyl-5-(3-methyl-4-hydroxyphenyl)pyrazole; 4-Desmethyl-3-methyl SC-58635; Celecoxib Impurity F (according to some sources)
EINECS	Contact for details

Quality Control

Our 4-Desmethyl-3-Methyl Celecoxib is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets high-grade standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.